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Symptoms: Signs and symptoms associated with memantine overdosage in clinical trials and from worldwide market experience alone or in combination with other drugs and/or alcohol include agitation, asthenia, bradycardia, coma, confusion, dizziness, electrocardiogram (ECG) changes, increased blood pressure, lethargy, loss of consciousness, psychosis, restlessness, slowed movement, somnolence, stupor, unsteady gait, visual hallucinations, vertigo, vomiting and weakness.
Treatment: Utilize general supportive measures and symptomatic treatment. Elimination of memantine can be enhanced by acidification of urine.
